Jumat, 24 Desember 2010

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  • Published on: 1900
  • Binding: Paperback

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Kamis, 23 Desember 2010

[T794.Ebook] Download Handbook of Statistics in Clinical Oncology, Third EditionFrom Chapman and Hall/CRC

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Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research.

Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts:

  • Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents.
  • Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs.
  • Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials.
  • Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added.

Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

  • Sales Rank: #1013420 in Books
  • Published on: 2012-03-26
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.10" h x 1.70" w x 6.40" l, 2.25 pounds
  • Binding: Hardcover
  • 657 pages

Review

"A strength of the handbook is the large number of examples that are included in most chapters that expand on the theoretical basis underpinning the relevant methodology. Each chapter provides details of new developments in the specific methodology and provides a comprehensive list of references for the reader to seek further information when required. … The book contains a wealth of information about a wide range of statistical methodologies, some of which are not limited to clinical trials. … a valuable update to a resource that covers a comprehensive range of topics related to the design, analysis and interpretation of clinical trials in cancer research."
―Peter Baade, Australian & New Zealand Journal of Statistics, 2013

Praise for the Second Edition:
"The new topics and contributions in this edition include the recently developed tools for high-dimensional data and bioinformatics in clinical oncology research. A new section has been added emphasizing the importance and rapid developments of these topics over the 5 years since the publication of the first edition. Some of the original sections have been updated to include the state-of-the-art knowledge and tools in all topics. The end result is a comprehensive edited volume covering statistical and bioinformatics methods that provide the foundation for important research and clinical trials in cancer. … Like the last edition, this current edition will be an important addition to the libraries of all health research centers. The book will be prized as a reference book for biostatisticians, biomedical researchers, and oncologists for planning, conducting, analyzing, and interpreting cancer research."
―Journal of the American Statistical Association, Vol. 104, No. 487, September 2009

"This is a expanded and revised second edition of a text that was initially well received by the community. The book comprised of 33 chapters, grouped into 6 sections. … The text is extremely well referenced. The authorship represents the leaders in the field. A significant strength of this book is its example-driven approach to the ‘out-of-the-box’ but practical issues faced by those conducting cancer clinical trials. The book provides a critical assessment of the state of science through a thorough review of the methods, applications, and available resources. … a detailed and mostly comprehensive text on the topics of cancer clinical trial design, conduct, analysis, and interpretation."
―Daniel Sargent, Sumithra Mandrekar, and Ann Oberg, Mayo Clinic, Biometrics, December 2006

About the Author

John J. Crowley is president and CEO of Cancer Research and Biostatistics (CRAB), Seattle, Washington, director of the SWOG Statistical Center, and a faculty member at the Fred Hutchinson Cancer Research Center. The author or coauthor of more than 350 refereed articles, book chapters, and other publications, Dr. Crowley is a fellow of the American Statistical Association and the American Association for the Advancement of Science and a member of the International Biometrics Society, the American Society for Clinical Oncology, and the International Association for the Study of Lung Cancer. He received his BA (1968) from Pomona College, Claremont, California, and his MS (1970) and PhD (1973) in biomathematics from the University of Washington, Seattle.

Antje Hoering, PhD, is a senior biostatistician at Cancer Research and Biostatistics (CRAB), Seattle, Washington. She is also an affiliate faculty member in the Department of Biostatistics at the University of Washington and an affiliate investigator at the Fred Hutchinson Cancer Research Center. Dr. Hoering is the lead statistician of the SWOG Myeloma Committee, the SWOG Early Therapeutics Subcommittee, and the Stand Up To Cancer, Pancreatic Dream Team. She is the coordinating statistician for the Myeloma Institute for Research and Therapy, the International Myeloma Committee, and the Pancreatic Cancer Research Team. She serves as a consultant on a variety of industry-sponsored studies and has been the biostatistics representative on two Type B meetings with the FDA. She is member of the American Statistical Association, the International Biometrics Society, and the International Myeloma Society. She received her BS (1985) from the University of Tubingen, Germany, her MS (1988) in physics from Oregon State University, Corvallis, and her PhD (1991) in physics from the Max Planck Institute for Theoretical Nuclear Physics, Heidelberg, Germany. She transitioned into biostatistics with a three-year NRSA postdoctoral fellowship with the Department of Biostatistics at the University of Washington and the Fred Hutchinson Cancer Research Center.

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Senin, 06 Desember 2010

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  • Published on: 1600
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Minggu, 05 Desember 2010

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  • Sales Rank: #1071013 in Books
  • Published on: 1973
  • Ingredients: Example Ingredients
  • Number of items: 1
  • Binding: Hardcover
  • 314 pages

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  • Sales Rank: #6323048 in Books
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Sabtu, 04 Desember 2010

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As the architecture of the soul, the chakra system is the yoke of yoga―the means whereby mind and body, heaven and earth, and spirit and matter are joined together in the divine union that is the true meaning of yoga. 

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  • Sales Rank: #16277 in Books
  • Published on: 2015-09-08
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.22" h x .57" w x 7.54" l, 1.00 pounds
  • Binding: Paperback
  • 454 pages

About the Author

Anodea Judith, PhD is the founder and director of Sacred Centers, and a groundbreaking thinker, writer, and spiritual teacher. Her passion for the realization of untapped human potential matches her concern for humanity's impending crises―her fervent wish is that we "wake up in time." She holds Masters and Doctoral degrees in Psychology and Human Health, with lifelong studies of alternative medicine, yoga, mythology, history, sociology, systems theory, and mystic spirituality.

She is considered one of the country's foremost experts on the combination of chakras and therapeutic issues and on the interpretation of the Chakra System for the Western lifestyle. She spends much of her time on the road teaching, with workshops and trainings offered across the US, Europe, and Central America.

Most helpful customer reviews

16 of 16 people found the following review helpful.
Necessary addition to any yoga/chakra library
By Rose Kress
Psychologist and yogin Anodea Judith is an amazing resource when it comes to the chakra system. Her first book, Wheels of Life: A User’s Guide to the Chakra System, has become a yoga classic. Now she has released a book specific to hatha yoga practice using the chakras. This is a great resource for individuals who may wish to focus their practice on a specific chakra, as well as a manual for teachers who wish to lead a chakra yoga practice. Chakra Yoga can be used by novices who would like to learn about the chakras, experienced practitioners looking for ideas or perspective, and everyone in between. To put everyone on the same page, Judith gives a concise and thorough explanation of the chakras.

Judith gives a short introduction, where she introduces the reader to her personal and professional experience with chakras. She then places the chakras into the context of yoga (some may have encountered chakras at the new age store and not know their yogic origins). Yoga means “to yoke,” or hitch two things together and Judith says, “the chakra system is the architecture of that yoke, providing a comprehensive map to the way the mortal and the Divine yoke together.” The goal of the chakra, yoga, and LifeForce Yoga is wholeness and integration. The chakra system “provides both a ladder for liberation and a map for manifestation.” Understanding our chakras and integrating this knowledge into our practices, allows us to have a deeper experience of focus and unfolding.

Each chapter is devoted to a specific chakra and begins with a chart of the basic principles of that chakra. These principles include things like associated element, body parts, practices, actions, deficiencies, balances, etc. Judith identifies a keyword for each chakra, which is elaborated upon in the discussion of basic concepts that follows. As an example, the keyword for Manipura, third chakra, is activate, through the cultivation of fire (agni) in the body. This concept of activation through fire is put into context with a discussion of the underlying yogic philosophy with sources from the Yoga Sutras of Patanjali and the Bhagavad Gita. The author then grounds this discussion into an experience, pelvic pulsing for the second chakra, uddiyana bandha (energy lock) for the third chakra, etc. The energy practice is followed by a meditative experience, a subtle energy exploration of the chakra.

The chapter continues with a yoga posture flow. Judith states in the introduction that there is no substitute for a skilled teacher and since this is not a comprehensive yoga pose manual, she has made some wonderful adjustments. Postures have a basic set of step by step instructions and readers are asked to follow them in order without omission. Guidelines are given for further instruction, as well as benefits and cautions. At the end of the chapter, a posture flow is given with the names of the poses and a small photograph. The selection of which postures to include is not easy as postures influence more than one chakra at a time, or variations of the same pose, or a shift in focus, may impact a different chakra. For this reason, Judith states, “some of the basic poses will appear in more than one chakra.” Of special note: the author provides a four pose partner yoga sequence in the heart chakra chapter.

Judith provides a specific relaxation and focus for each chakra. For example, the focus of relaxation for the fifth chakra (visshudha at the throat) is on “listening to the subtle variations coursing throughout the whole body.” The relaxation focus for the first chakra (muladhara at the base of the spine) is on feeling the solidity of the body and receiving nourishment from the earth.

Judith is adept at writing about complex concepts from yoga philosophy so that they are easy to understand and yet lose none of their richness. Chakra Yoga contains ample opportunities to experience energy, movement, and stillness. It belongs on the shelf of every yoga/chakra enthusiast.

14 of 15 people found the following review helpful.
It is Beautiful, Clear
By adrienne gammal
Anodea Judith has created another masterpiece! This is the motherload of Chakra Yoga poses and information, the visual and directional book we all have been waiting for.
It is Beautiful, Clear, Concise and Easy to follow, a true Chakra Bible and must have for your journey.

5 of 5 people found the following review helpful.
A unique experience!
By Cheryl Haley
Wow! There may be other yoga books, but not like this one! The detailed instructions and color photographs create such a seamless process that the experience just flows off the page into the reader. And the underlying principles and philosophy are brought to life with a wisdom and a depth that invites a personal application that is both timely and timeless. Well done! Thank you!

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Jumat, 03 Desember 2010

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Trade Me (Cyclone) (Volume 1) Paperback - January 20, 2015, by Courtney Milan

  • Published on: 1605
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